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Editors Selection IGR 16-4
Basic Research Animal Studies: Aqueous humor dynamics in OH monkeys
Comment by Paul Kaufman on:
27132 Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension, Toris CB; Risma JM; Gonzales-Martinez J et al., Experimental Eye Research, 2010; 91: 860-865
Toris et al. (1629) describe the aqueous humor dynamics in a strain of rhesus monkeys inbred to be ocular hypertensive. The goals were to provide a primate model for human glaucoma, to study the pathophysiology of aqueous humor dynamics and the optic neuropathy that characterize this primate model, and perhaps to develop and test novel therapeutics to treat these conditions. The authors found that IOP was higher, and that outflow facility, uveoscleral outflow, and overall aqueous flow were lower in the ocular hypertensive animals than in an appropriate control group.
Unfortunately, the flow values in the control animals were higher than the normal range seen for this species, and this plus the assumptions involved in calculating some of the other parameters limits the usefulness of the findings. The characterization of the aqueous humor dynamics in this model would benefit from more direct albeit more invasive measurement of the relevant parameters. Invasive measurements would be a big step in these valuable animals, but their real value is understanding their hydrodynamics with greater certainty than this report provides.
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