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Editors Selection IGR 24-3

Clinical Forms of Glaucoma: Aqueous flare in APAC and CPACG

Comment by Minguang He on:

27452 Damage to the blood-aqueous barrier in eyes with primary angle closure glaucoma, Kong X; Liu X; Huang X et al., Molecular Vision, 2010; 16: 2026-2032

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Kong et al. (1806) reported the anterior chamber inflammatory reaction in eyes with acute PACG (APACG), chronic PACG (CPACG) and normal wide-angle controls. Aqueous flare and cells were determined by a laser flare photometry. The means of aqueous flare value were 141.4 in APACG, 7.7 in CPACG and 4.5 in normal wide-angle eyes. The study is interesting and among the first to document anterior chamber inflammatory responses in angle-closure eyes using objective measurements. The findings are consistent with clinical findings when slit lamp is used and it is not particularly surprising to see damage of blood aqueous barrier with the acute ischemia of anterior segment. However, the mild but statistically significant IOP elevation in chronic angle closure is interesting. This could be attributable to either IOP elevation or angle closure itself. It would have been helpful if the study could involve the cases with POAG with IOP elevation, the fellow eyes of acute attack and narrow-angle eyes as the controls, so that the role of IOP elevation and angle closure could be further explored.

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