advertisement
Top-Ten Japanese Glaucoma Society Meeting
September 24-26, 2004, Niigata, Japan
Makoto Araie
- An analysis of 194 high-pressure glaucoma patients, 217 normal-pressure glaucoma patients, and 218 normal controls, showed correlations between the promoter polymorphism of TNF-a gene and optineurin gene polymorphism in prevalence of glaucoma and degree of visual field loss.
- lthough trabeculectomy with adjunctive use of mitomycine C for normal pressure glaucoma may result in a statistically significant reduction of IOP over 4 years, only 40 % of patients obtained 30% reduction from the baseline.
- In a Japanese population based survey, 39 of 3021 subjects (1.3%, CI:0.9-1.7%) were found to have visual disability or blindness on the basis of WHO standards. Of these, only 5 were due to glaucoma.
- Parameters of Heidelberg Retina Tomography were significantly different among various types of glaucomatous optic nerve heads (except for the rim area).
- During measurements of diurnal variation of ocular perfusion pressure
in normal-pressure glaucoma patients, ocular perfu
sion pressures were significantly lower at 21:00 and at 24:00 than those measured at other times, although such a difference was not observed in patients with high-pressure glaucoma. - The results of Humphrey Matrix visual field, central 10-2 showed a good correlation with those by Humphrey visual field 10-2, particularly in the nasal inferior region.
- Histological examination of a specimen of the trabecular meshwork obtained from a patient with glaucoma secondary to vitreous injection of triamcinolone showed no specific abnormalities resembling steroid glaucoma.
- Candesartan (an angiotensin II receptor inhibitor) reduced intraocular pressures of normal volunteers significantly for six hours without showing any significant cardiovascular side effects.
- In diurnal variation of the intraocular pressures of ddY mice, a double hump pattern was observed in those under conditions of darkness and brightness each for 12 hours.
- In normal-pressure glaucoma patients, diurnal variations of the nerve fiber layer thickness evaluated by GDxVCC were observed, particularly in the region of nerve fiber layer defects.
