Top-Ten of the American Glaucoma Society Annual Meeting

March 3-6, 2005, Snowbird, Utah, USA

Jeffrey Liebmann and James Brandt

• Analysis of the data from the Ocular Hypertension Treatment Study did not detect an increase in cataract formation in eyes receiving medications to lower IOP compared to untreated eyes.
• An economic analysis of the data from the Ocular Hypertension Treatment Study suggests that ocular hypertension deserves to be treated when the risk of conversion to glaucoma is at least two percent per year. Treatment need not be delayed until visual field loss or progressive optic nerve injury develops.
• In a prospective assessment of latanoprost, travoprost, and bimetaprost using a crossover design, these agents were found to increase uveoscleral and pressure-dependent outflow, but not affect aqueous humor production.
• Modelling of the primate optic nerve head to provide quantitative characterization and visualization of the macro and micro-architecture of the neural and connective tissue will enhance our understanding of the physical properties of the optic nerve and the response of these tissues to intraocular pressure and other risk factors for disease pathophysiology.
• Optical coherence tomography of the anterior segment can provide meaningful information regarding angle anatomy in a non-invasive (non-contact) fashion.
• Properties of the cornea other than its thickness, such as corneal hysteresis, may be independent predictors of glaucoma progression. Although significant in the univariate model, this association was less prominent in the multivariate model and requires further investigation.
• Racial differences in ocular anatomy likely impact the results of imaging devices currently used in glaucoma diagnosis and management. Future normative databases should have race-specific information.
• There is little consensus regarding which visual field algorithm should be used in clinical practice. In this study utiliziing visual field data from the Advanced Glaucoma Intervention Study, glaucoma change probability analysis was better able to predict disease progression than point-wise linear regression.
• Physician treatment of disease is not uniform for all ethnic groups and gender. In this study, the authors demonstrate that women are not treated as frequently as men for a given level of disease. This information has ramifications for current treatment paradigms of glaucoma and glaucoma suspects.
• Removal of the trabecular meshwork and inner wall of Schlemm's canal is possible using new technology. Initial results with the Trabectome suggest that it may have future potential as a treatment of open angle glaucoma.
  
   

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