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Top-Ten of the American Glaucoma Society Meeting

March 1-4, 2007, San Francisco, CA, USA

Leon Herndon

1. Longitudinal analysis of 44 glaucomatous eyes revealed poor agree-ment between structural (OCT) and functional (VF) progression detection. Detectable structural changes frequently may not precede detect

2. In a study of 384 eyes, the area of the optic disc and the optic cup was larger with a deeper cup in eyes from non-glaucomatous individuals of African descent compared to those of European descent.

3. Outflow facility in young healthy adults measured by tonography decreases by a small amount during the nocturnal period, however, the change is not sufficient to compensate for the decrease in aqueous flow rate.

4. OAG patients report a decline in Quality of Life compared to individuals without glaucoma. This reduced QoL correlates strongly with reduced VA, severity of visual field defects and the presence of binocular field defects.

5. 347 patients who were on either anticoagulation therapy or antiplatelet aggregation therapy prior to glaucoma surgery had a higher rate of hemorrhagic complications than 347 case-matched control patients. Continuation of anticoagulation therapy, but not antiplatelet aggregation therapy during glaucoma surgery is associated with a significantly increased rate of hemorrhagic complications.

6. 25 patients with a functional glaucoma drainage tube shunt and continued uncontrolled intraocular pressure underwent 360° of endocyclophotocoagulation treatment. At 24 months, the mean IOP dropped 23.3% and the mean number of medications dropped from 3.2 prior to laser to 2.

7. In a study of human glaucoma eyes and age-matched control eyes, normal tau protein was reduced in glaucoma compared to controls. abnormal tau AT8 was observed in the posterior retina in glaucoma and not in controls.

8. Eyes that are medically managed show greater IOP fluctuation and peak following the water drinking test than surgically controlled eyes.

9. A study of 112 patients who had successful tension suture implantation with canaloplasty showed a 38% IOP drop at 12 months with low rates of surgical complications.

10. A study of 204 patients who underwent ab interno unroofing of Schlemm's canal with the Trabectome showed a 42% IOP reduction from preoperative values out to three years with minimal postoperative complications.