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Top-Ten of the Annual Meeting of the Japanese Glaucoma Societ
Osaka, Japan, September 12-14, 2008

Atsuya Miki and Yasuaki Kuwayama (Osaka, Japan)

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1. Spectral domain OCT showed higher sensitivity than red-free fundus photography in detecting retinal nerve fiber layer defects in 35 OAG (NTG+POAG) patients with high myopia (≤ -6D, 71.7% vs. 40.4%), whereas both methods showed similar sensitivity in 30 OAG patients without high myopia (66.3% vs 48.8%) (S. Konno, Tokyo).
2. To evaluate IOP-dependent retinal ganglion cell (RGC) loss without invasive staining in animal models, the numbers of viable RGCs were counted and compared between laser-treated high IOP eyes and non-treated fellow eyes in mice which express cyan fluorescent protein (CFP) in RGCs. A reduction in the number of RGCs was demonstrated in all of the laser-treated eyes. A significant negative correlation between the survival of RGCs and cumulative IOP load was observed (H. Tsuruga, Tokyo).
3. The association of SNP rs1048661 of the lysyl-oxidase-like 1 (LOXL1) gene with the occurrence of exfoliation syndrome (XFS) in the Japanese population was investigated. An analysis of 268 XFS patients and 362 normal control subjects revealed the strong correlation of rs1048661 with XFS. However, the distribution of alleles in the Japanese population was different from that of the Caucasian population: The risk-associated allele in the Japanese population was T (Thymine), whereas that of the Caucasian population was G (Guanine) (N. Gotoh, Kyoto).
4. In 1000 eyes in 510 Japanese patients with primary angle-closure suspect, primary angle closure or primary angle-closure glaucoma, corneal endothelial damage (cell count ≤ 1500 cells/mm2) was observed in 3.1%. The prevalence of corneal endothelial damage was especially high in eyes that had undergone laser iridotomy (5.8%), and in eyes with a history of acute primary angle closure (12.7%). (A. Nonaka, Kobe)　
5. In a retrospective review of 56 eyes of 56 patients with NTG followed up with one- to two- months' interval for at least five years, disc hemorrhage was associated with the expansion of retinal nerve fiber layer defects. (K. Nitta, Fukui)
6. An analysis of cross-sectional filtering bleb images in the early postoperative period obtained with anterior segment OCT and ultrasound biomicroscopy (UBM) revealed that blebs with high-intensity walls had poorer function than those with low-intensity walls. Low-intensity blebs with cystic cavities tended to become avascular well-functioning blebs, whereas low-intensity blebs without cystic cavities tended to become vascular well-functioning blebs in the later postoperative phases. (M. Hangai, Kyoto)
7. In a study including 27 eyes of 27 patients with early glaucoma and 30 eyes of 30 patients with glaucoma suspect, frequency doubling technology (FDT), flicker perimetry and short wavelength perimetry (SWAP) correlated more strongly with retinal nerve fiber thickness measured with OCT than standard automated perimetry (SAP). (H. Nomoto, Osaka)
8. Apolipoprotein E (apoE)-containing lipoproteins (LPs) protect cultured RGCs from apoptosis via a low-density lipoprotein receptor-related protein (LRP)-mediated signaling pathway. Phospholipase C (PLC) plays an important role on this neuroprotective effect. (H. Hayashi, Kumamoto)　
9. An analysis of 110 eyes in 110 normal volunteers revealed that both occlusion of unexamined eye and taking breaks between first and second eye examination are effective in preventing blank out phenomenon in the Humphrey matrix perimetry. However, the blank out phenomenon does not influence the results of perimetry. (S. Takada, Fukui)
10. A study of 39 patients who underwent 360-degree suture trabeculotomy showed significant reduction of IOP from 27.4 ± 11.7 mmHg to 12.5 ± 3.5 mmHg (three months postoperatively). (T. Nitta, Sapporo)