(IGR: 13-4) | International Glaucoma Review #

Top-ten Chinese Glaucoma Society Meeting
Bejing, P.R. China, September, 2011

Measured with 3 Tesla magnetic resonance imaging, the optic nerve subarachnoid space was narrower in normal-pressure glaucoma patients than in high-pressure glaucoma patients, suggesting a lower orbital cerebrospinal fluid pressure in normal-pressure glaucoma. (Ningli Wang, et al., Beijing, P.R. China)

This study revealed that the SLCCs of the WERI-Rb1 line expressed embryonic stem cell- and retinal stem cell-related genes and they could be further induced into retinal neurons through blockade of endogenous Wnt and Nodal signals. These findings utilized a strategy of the artificial change of cancer stem cell fate by transcription factors and may provide a new insight for cell replacement strategy of retinal degeneration disease. (Huiling Hu, Fei Deng, Mengfei Chen, Jian Ge Kaohsiung, Guangzhou, P.R. China)

By direct DNA sequencing the CYP1B1 Gene in 238 cases of Primary Infantile Glaucoma, investigating the genotype-phenotype relationship, and reviewing the operative effect, the mutant CYP1B1 gene was found to be partly related with the infantile glaucoma (17.2%). The carriers of the mutant CYP1B1 gene may be at earlier onset and with poorer corneal transparency. Mutant CYP1B1 gene is the protective factor for operative effect, and the patients with it have higher success rate and longer successful time. (Xueli Chen, Yuhong Chen, Xinghuai Sun, Shanghai, P.R. China)

Polymorphisms of the α2B-, α2C- and β1-adrenergic receptor gene influenced untreated intraocular pressure levels in diurnal intraocular pressure curves of Japanese patients with normal-tension glaucoma. However, no polymorphisms were associated with IOP range in diurnal intraocular pressure curves. (Yanlin Gao, et al., Kanazawa, Japan)

With diffusion tensor MRI, it was found that the optic tract and optic radiation were injured in primary open angle glaucoma patients, and they varied consistently with clinical severity of glaucoma（damage to the optic disk and loss of visual function. (Chen, et al., Wuhan, P.R. China)

Compared to Wide Type(WT) mice, constitutive overexpression of Neuroglobin(Ngb) in transgenic mice prevented Retinal Ganglion Cell(RGC) damage induced by chronic IOP elevation for 1,4,8 weeks. It suggest that Ngb protects RGC , at least in part, through reducing reactive oxidative products and preserving the function of mitochondria. (Xin Wei, Xiaomin Chen, Xuyang Liu, D.Chen, Chengdu, P.R. China)

The prevalence of sleep disturbances was higher in patients with POAG and PACG than in controls. This study indicates that glaucoma not only damage the visual function, but also the non-image-forming function like circadian rhythms. (Ye Zhan, Huaizhou Wang, Ningli Wang, Beijing, P.R. China)

Mitochondria targeted peptide MTP-131 could protect against oxidative stress and alleviate apoptosis in RGC-5 cells, which might have potential neuroprotective effect in POAG. (Min Chen, Bingqian Liu, Yujing Bai, Jian Ge, Guangzhou, P.R. China)

This study was performed to determine if the viruses are possible etiologic agents in Posner-Schlossman syndrome (PSS). The specimens from aqueous humor and peripheral blood were assayed to detect HSV, VZV, EB, AD, RV and CMV by PCR, IFT and ELISA. The results showed that CMV DNA positive ration was 30% in aqueous humor, which was higher than other viruses. CMV infection may play an important role in the pathogenesis of PSS, and antiviral therapy could be effective. (Xiaolei Wang, et al., Shanghai, P.R. China)

By proteomic analysis, immunofluorescence, immunoblotting and Prussian blue staining, we demonstrated that non-iron-chelated hemoglobin was observed to be highly expressed in avascular human lens capsule, pseudoexfoliation (PXF) material and aqueous humor. Over a decade ago, several groups suggested a low molecular weight protein was associated with PXF glaucoma. We have identified this molecule to be hemoglobin. (Xiangmei Kong, Miguel Risco, Richard K. Lee, Shanghai, P.R. China)