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Top Ten AGS 2001
March 1-3, 2001, Newport Beach, CA, USA
Mark Sherwood
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Scanning laser tomographic and visual field changes in a prospective study of glaucoma patients
Eighty-eight percent of patients with visual field changes also had optic disc changes, however, less than half the patients with optic disc changes had visual field changes (58.4%). When both disc and field changes were present the disc changes were detected slightly earlier (median =18 months). (Balwantray C. Chauhan) -
A new method of objective VEP perimetry
This new VEP system objectively tests 58 points in the central visual field extending out to 34° nasally. It identified all HVF defects and also showed up definite defects in the 'normal' contralateral eye of 26 glaucoma patients. (Ivan Goldberg) -
The effects of ischemia on the anterior optic nerve
In a chronic ischemia model in rhesus monkeys, induced by endothelin-1 infusion, a preferential decrease was seen in axonal counts, in the superior and inferior regions of the optic nerve, and this corresponded to reactive astrocyte proliferation and hypertrophy in the same areas. (George A. Cioffi) -
Is glaucoma primarily a disease of glial dysfunction?
A co-culture of RGCs and glial cells exposed to stressful conditions such as ischemia and elevated hydrostatic pressure showed apoptosis of the RGCs. The apoptosis was attenuated 66% by a neutralizing antibody to TNF-a and 50% by a selective inhibitor of NO synthetase. (Martin B. Wax) -
Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model
Induction of heat shock protein 72 (Hsp) in an experimental rat model of glaucoma seemed to confer a protective effect on retinal ganglion cells after four weeks of elevated intraocular pressure as compared with controls. (Joseph Caprioli) -
Measurement of the anterior chamber angle in Eskimos, Chinese, Blacks and Whites
Using biometric gonioscopy (BG), this study confirmed the high prevalence of angle-closure glaucoma among Eskimo and Chinese populations. (Nathan G. Congdon) -
The long-term outcome of glaucoma filtration surgery
Filtration surgery is associated with a 54% probability of preservation of vision from progression to legal blindness at ten years after surgery. Those who went blind had more advanced field loss prior to surgery and their IOP was similar to those retaining vision. (Douglas H. Johnson) -
Glaucoma bi-pass surgery I: device development; II: surgical technique and feasibility studies
In vitro and animal studies of a new inverted 'Y'-shaped silicone glaucoma implant (the bonded portion is inserted into the anterior chamber and the legs are passed into Schlemm's canal on either side) showed excellent tolerability of the implant both clinically and histologically. There were no visible blebs in any of the animals. (Mary G. Lynch; Reay H. Brown) -
Gelatinase B (MMP-9) in leaking filtering blebs
A 92-kDa gelatinase of a size appropriate for gelatinase B (MMP-9) was found in leaking bleb tissue, as well as in the leaking bleb fluid and aqueous humor. It was absent in non-leaking bleb tissue. (Joel S. Schuman)