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Top-Four of the 27^th American Glaucoma Society Meeting
Coronado, California, USA, March 2–5, 2017

Steven J. Gedde and Felipe A. Medeiros

1. Steven Gedde, Miami, FL, USA
   Treatment Outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study After one Year of Follow-Up
   The Primary Tube Versus Trabeculectomy (PTVT) Study is a multi-center randomized clinical trial comparing the safety and efficacy of tube shunt surgery (350-mm2 Baerveldt glaucoma implant) and trabeculectomy with MMC (0.4 mg/ml for two minutes) in eyes without previous incisional ocular surgery. Trabeculectomy with MMC produced greater IOP reduction (13.8 mm Hg vs 12.4 mmHg, p = 0.012) with use of fewer glaucoma medications (2.1 vs 0.91, p < 0.001) and a higher success rate (92.1% vs 82.7%, p = 0.013) compared with tube shunt implantation after one year of follow-up.
   
   
2. James Brandt, Sacramento, CA, USA
   Reduction in IOP from a Sustained-Release Bimatoprost Ring: Pooled Results from two Open-Label Extension Studies
   A pooled analysis was performed of two open-label extension studies evaluating the sustained-release bimatoprost ring. The novel drug delivery device achieved a continued four to six mmHg reduction of IOP for six months in patients with open-angle glaucoma and ocular hypertension. Adverse events were generally mild and resolved. Retention of the insert was observed in 92.3% of subjects.
   
   
3. Pradeep Ramulu, Baltimore, MD, USA
   Evaluation of Activity-Normalized Fall Rates in Glaucoma
   Fall rates were prospectively evaluated in subjects with varying degrees of VF loss from glaucoma, and falls data were combined with accelerometer-defined physical activity to express fall rates as a function of both time and activity. Fall rates were found to increase with VF damage in glaucoma (23% higher rate of falls per step/5 dB decrement in integrated VF, p = 0.01). Inferior field loss, particularly outside the central 24 degrees, was most strongly predictive of falls.
   
   
4. Gustavo De Moraes, New York, NY, USA
   24-Hour IOP-Related Profile with a Contact Lens Sensor Is Associated with Visual Field Progression in Treated Glaucoma Patients: A Multicenter Study
   This multicenter study evaluated the relationship between VF progression and IOP-related parameters obtained during a 24-hour recording with a contact- lens sensor (Sensimed Triggerfish). Number of long and brief peaks, mean peak ratio, variance from the mean, amplitude of the cosine curve, and waketo- sleep slope were associated (p < 0.10) with faster VF progression. The combined predictive model had an R² of 0.303 and RMSE of 0.250 with an average predictive error of the MD slope of -0.03dB/year.