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11-2
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Issue 11-2
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IGR 11-2
Patients with glaucoma show greater difficulty in performing safe driving tasks, especially when moderate or severe bilateral damage is present
Neuroprotective effects in animal studies may depend heavily on dose of neuroprotectant, and possibly route or mechanism of delivery
The clinical significance of long-term IOP fluctuations remains unclear
Particularly patients with concentric optic disc appearance might have a higher IOP during the night
The most important determinants of ONH biomechanics remain the stiffness of the sclera and the lamina cribrosa
Measuring the RNFL thickness with digital imaging instruments is likely to become anew paradigm for the objective assessment of glaucoma progression
There is a growing body of evidence that vascular dysregulation and fluctuation of ocular blood flow occur in glaucoma patients
Axial length separately influences ONH susceptibility in glaucoma
EP2 and EP4 agonists, but not EP1 and EP3 agonists, reduce IOP in mice
Collagen and extracellular matrix turnover is dynamic and affects glaucoma drainage implant function
Conservative management of small conjunctival leaks and more interventional management of larger ones seems to be reasonable and not to adversely affect trabeculectomy outcomes
Providing payment for the glaucoma examination is good use of social resources
Stem cell transplantation could confer neuroprotection in patients suffering from neurodegenerative diseases including glaucoma
The involvement of a candidate gene in the disease is better established when its involvement is established in diverse populations worldwide
Clinical IOP assessment for glaucoma diagnosis and treatment is severely restricted by time and by the technical requirements of a measuring device
Verifying clinical dogma and impressions through rigorous objective clinical research is important
While many eye care guidelines are supported by research findings, unanticipated and surprising results can sometimes occur when proper clinical research is conducted
Measurements taken on one instrument cannot be used or compared to those taken from a different instrument One needs to baseline each person when switching to a new instrument
The mouse model offers the ability to further substantiate data obtained with pharmacological tools through the use of knock-out animals
Studies on the use of preservative free and preservative containing anti-glaucoma drops should focus on merging clinical and diagnostic findings with patient reported symptoms to tease out any significance to reported findings
Poor physician-patient communication, lack of instruction, a perception that not taking drops is safe, and difficulty taking drops when traveling or altering one's schedule all are important causes of failure to adhere to drug taking regimens
A call for caution with the election of transcorneal electrical stimulation as strategy to overcome visual diseases has to be considered
Axon degeneration was delayed by the application of electrical stimulation in a small proportion of the axon population
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