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Issue 11-4
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IGR 11-4
Driving endpoints as secondary endpoints in glaucoma
Physical exercise may reduce the likelihood of developing glaucoma (
Diffusion tensor imaging is a promising tool to evaluate neural degeneration in glaucoma
A viral vector mediated gene transfer has the ability to deliver a completely ectopic PG synthesis/response system for the long term that is functionally equivalent to topical drop therapies and is a potential step forward in glaucoma therapeutics
Non-invasive imaging is a powerful technique to study RGC degeneration
Concordant patterns of ganglion cell complex (GCC) and RNFL loss will greatly improve a clinician’s confidence of glaucomatous damage in the context of equivocal or unreliable visual fields
Is visual field progression linear?
After fifteen years of research into the subject, visual field deterioration in glaucoma is still well described by a linear model of the rate of change
Progressive changes of the optic disc are highly predictive of visual field progression
No longitudinal study has shown that a ‘plateau’ appearance worsens the long-term outcome
The eye as a ‘window to the mind’ may turn out to be more than poetic license, after all
Surgical outcomes are affected by the criteria used to define success
The debate on tube versus trabeculectomy will remain for as long as we have an imperfect operation
Incorporation of life expectancy information into predictive models for glaucoma becomes of fundamental importance in the decision-making process
Awareness of having an ocular disease is not sufficient in itself to impact Quality of Life
Ciliary tissue transplantation may restore intraocular pressure in prolonged hypotony
Trabeculectomy with MMC has a higher probability of success when greater IOP reduction is desired
Multifocal pupillography still requires the patient’s cooperation and understanding
Investigation of Thy-1 CFP DBA/2J mice may provide mechanistic insight of retinal ganglion cell (RGC) degeneration in glaucoma and identify potential therapeutic windows to promote RGC survival
Macular imaging and RGC quantification may be more sensitive than VF testing if early glaucomatous defects in this region are discrete and lie between VF test locations
Patients in whom linear regression analysis suggests dangerously rapid rates of visual field progression may be candidates for significant alterations in therapy
More evidence is needed to conclude that rates of visual field deterioration are linear over the time course of the disease
One should exercise caution when trying to predict future visual field loss from linear regression estimates of initial visual field data
RNFL parameters performed significantly better than ONH and macular thickness parameters
Exercise has an additive effect of lowering intraocular pressure regardless of the class of ocular hypotensive medication, or the number of medications
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