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WGA Rescources

News Flashes IGR 24-1

Vision after ab-interno procedures is less prone to early post -op fluctuation, but with typically less IOP reduction as the compromise

The study, however, was limited by its single site, small sample size, short follow-up and focus on IOP endpoints only. In addition, patients were woken for IOP measurements, which were taken in the sitting position, perhaps not reflecting actual IOP variation

The study is inherently limited by its cross-sectional design, which precludes establishing causality. While the use of ICD-10-CM codes for diagnosis is a practical approach for large-scale studies, it might introduce misclassification bias

While a significant number of patients with the MicroShunt experienced hypotony this was well-tolerated and did not adversely affect visual acuity

This is an important finding, as it corroborates clinical impressions that those angles that remain appositionally closed after LPI may be at higher risk of disease progression and require closer follow-up.

A common findings across sites were the lower rate of male enrolment (a concern for glaucoma where global age-standardized rates of blindness exceed that among females)

Further, the previously observed associations of phospholipids and organic acids and mitochondrial dysfunctions in POAG were also seen in the present cohort

A rise in episcleral venous pressure and choroidal congestion are the main mechanisms for these pressure spikes

Mind-body interventions which induce relaxation with a lowering of IOP and other physiological benefits can potentially improve overall health related quality of life

One of the main limitations of this study, in addition to its retrospective nature, is the absence of a defined success criterion before surgery

The continuous regression scoring approach risks unbalanced learning or overfitting, particularly if there is an insufficient variety of training samples

Just because a structure is fluorescent in this mouse does not mean it is guaranteed to be a lymphatic

A direct communication between the trabecular/conventional outflow pathways and subconjunctival lymphatics will be interesting to study in glaucoma pathophysiology as well as for developing new eye pressure lowering therapeutics

The absence of statistically and, more importantly, clinically significant differences indicates that more complicated models may not provide any meaningful benefit to simpler models, such as Cox regression, even when their assumptions are not strictly met

One issue was the exclusion of the manpower costs associated with ophthalmic investigations in GLOC, which could significantly underestimate the cost of GLOC and overestimate its savings

Another issue was the lack of clarity on how visual field progression and progressive retinal nerve fiber layer thinning were determined

The study's limitations include reliance on administrative claims data, misclassification bias from coding the most severe diagnosis (rather than all diagnoses), and a lower myopia prevalence rate compared to other studies

Its results provide important insights into the potential of the bimatoprost implant, which I see as mostly two-fold compared to topical prostaglandin analogues: Firstly, adherence issues are bypassed through the single injection and tolerability seems to be better for patients. Secondly, it is possible that the stronger observed reduction in IOP fluctuations provide improved glaucoma control

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