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News Flashes IGR 6-3

A cross-sectional screening study in Japan found:
  1. A high prevalence of POAG of which most NPG
  2. That CCT in POAG-NPG is not different from controls
  3. That only 0.07% of screened subjects had unilateral blindness from glaucoma
  4. That over 90% of POAG were undiagnosed

Eighty percent of people legally blind because of glaucoma, are older than 70 and have a glaucoma history of two to ten years (Russian GS)

The frequently used statement of "10% risk for every mm IOP reduction" should be interpretated with knowledge of AR, RR, RRR and NNT (Thomas)

The sclera is an active component of the uveoscleral drainage pathway

There is only a slight difference between lowering IOP by 25% or lowering CCT corrected IOP by 25% (Anderson)

In established glaucoma progressing at an unacceptable rate, the decision to lower IOP is unaffected by CCT (Anderson)

The sclera is more important than the lamina itself in determining what the lamina will do

Reduction in neuroretinal rim area accompanied by enlargement of the optic disc cup was found in women during the luteal phase

The integrated visual field test may be a useful measure to screen individuals' visual fitness with regard to driving

The combination of excavation CDR > 0.3 and visual field defects(MD < -2 dB) was found in 21 eyes of 12 patients with Systemic Sclerosis and in none of the controls

The risk of developing unilateral blindness is relatively low, meaning that only selected high risk ocular hypertension patients should be treated (Risk Management)

Risk factors should be distinguished from suspicion of damage; of course damage carries a risk of further damage (Risk Management)

The compliance of glaucoma patients did not exceed the level of 34,4%, in other words 65,6% of glaucoma patients do not use hypotensive eye drops regularly (Russian GS)

We should be more aggressive at earlier stages of the disease to prevent it from becoming a disease that is more expensive to treat

Over a period of 14 years 42% of OH patients died (Risk Management)

Adjunctive anti-TGF-2 human monoclonal antibody as an anti-scarring agent for phacotrabeculectomy: three-year results showed it was safe, but its effect on intraocular pressure was marginal and disappointing (RANZCO)

Trabeculectomy with 90-second exposure to 5-FU was as effective as five minutes, with fewer side effects (RANZCO)

Eyes treated with prostaglandin analogues have, on average, thinner corneas than their untreated counterparts or those treated with other medications

Viscocanalostomy appears to decrease outflow resistance through 'persisting' focal disruptions of the inner wall of Schlemm's canal (SC) and opening of the juxtacanilicular trabecular meshwork

Microscopic changes in laminar deformation might precede both nerve head change and RNFL damage (OGS)

The Dynamic Contour Tonometry IOP is most accurately correlated with the true manometric IOP

Reversal of cupping occurs after IOP reduction as measured with HRT

There was agreement between location of structural abnormalities (OCT) and functional defects (SWAP)

Actin architecture in the trabecular meshwork is markedly different in glaucoma vs. normals, correcting for age (OGS)

When appropriately scaled, a clear relationship exists between perimetric sensitivity and available structural surrogates of ganglion cell numbers. However, using a linear scale for both structure and function may complicate observations of the relationship because of how perimetric measurements are taken (OGS)

The practical significance of CCT is different in OHT and established glaucoma (Anderson)

Teleophthalmology may improve cost effectiveness in ophthalmology

The visual field sum of slopes analysis provides an additional useful tool for diagnostic purposes

Chronic elevated IOP does not affect Glutamate Synthetase expression levels in the retina

Issue 6-3

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