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Issue 7-2
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IGR 7-2
The diagnosis of systemic hypertension increased the likelihood of the diagnosis of glaucoma
Hypercholesterolaemia may be a risk factor for glaucoma
On multivariate analysis only IOP level, but not IOP fluctuation was significantly associated with progression
Early diagnosis of glaucoma may be enhanced by using progression as a criterion
No correlation was found between CCT and progression
NTG patients with systemic hypertension taking oral ACE-inhibitors were showing less progression than those who were not using oral ACE-inhibitors (Top-ten JGS)
Therapy for ocular hypertensives is complicated by inadequate compliance, side-effects, and failure to take effect of quality of life into account (ARVO-Quigley)
The evidence for a clinical effect of iridotomy on IOP in pigmentary dispersion remains week
Peripheral iridotomy may cause posterior subcapsular lens opacities
Removal of trabecular meshwork can effectively reduce the intraocular pressure in open angle glaucoma
Latanoprost and bimatoprost should not be used together
In addition to retinal ganglion cells, a subset of amacrine cells are also lost in a mouse glaucoma model
Patients with the OPTN mutation had an earlier age of onset, lower presenting IOP, greater optic nerve cupping, and required surgical treatment at a higher rate than the control group without mutations in OPTN
There is a pressing need to find an equitable balance between the individual glaucoma patient's liberty and society's demand for safe roads
Chronic Open Angle Glaucoma and Normal Pressure Glaucoma differ in predictive factors for progression
Infrared light gonioscopy permits evaluation of angle closure in the dark
A prevalence of POAG of 0.41% to 2.56% was reported in an epidemiological study in the India Chennai Glaucoma Survey. There is increase in prevalence with age (Top-ten GSI)
A prevalence of angle closure glaucoma in the India Chennai Glaucoma Survey was 1.58% and females were three times more likely to have angle closure than males (Top-ten GSI)
The overall prevalence of glaucoma (OAG + ACG) in the India Chennai Glaucoma Survey was 4.17% and 98.2% of cases did not have prior diagnosis of disease (Top-ten GSI)
The incidence of pseudo-exfoliation in South African blacks is 7% over the age of 40 and 18% over the age of 70 years, XFS is a cause of OAG in 9% of black South Africans (Top-ten SAGS)
Switching from latanoprost to bimatoprost failed to demonstrate a significant difference in IOP lowering
Lovastatin lowers IOP on perfused pig eyes
Normal conjunctival morphology was demonstrated after subconjunctival injections of Ilomastat
In prostanoid FP receptor knock out mouse, travoprost, bimatoprost, unoproston, tafluprost, as well as latanoprost did not show intraocular pressure lowering effects, while bunazosine chloride reduced the intraocular pressure significantly (Top-ten JGS)
There is a link between age, useful visual field and simulated driving ability
The likelihood of a diagnosis of glaucoma was increased in steroid users
A span of approximately 3 mm Hg excursion in intraocular pressure exists over a range of systolic BP levels between <110 and >200 mm Hg as well as over a range of diastolic BP levels between <70 and >120 mm Hg
Patients with obstructive sleep apnoea syndrome had a reduced RNFL thickness
An angiotensin receptor antagonist lowers IOP in rabbits
The probability of success (IOP less than 21 mm of Hg.) of trabeculectomy in childhood glaucoma was 94.5%, 92.1%, 86.7%, 79.4%, 72.9% and 63.1% at first, second, third, fourth, fifth and sixth year respectively. (Top-ten GSI)
Ocular pulsatile blood flow improved by almost 60% at 3 months follow-up after trabeculectomy in comparison to medical therapy with Timolol and Brimonidine. (Top-ten GSI)
Optic cup retinal stem cells (OC-RSCs) were isolated and cultured successfully from the cup of embryonic rat E12.5. RA and VEGF can be used as effective inducers to promote OC-RSCs' differentiation . (Top-ten ChinGS)
Aggressive immunomodulation with antimetabolites T-cell inhibitors or alkylating agents increases filtration surgery outcome in uveitic glaucomas dramatically to 94% success in 4 years. (Top-ten SAGS)
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