1. Home
  2. Issue 9-2
  3. News Flashes

advertisement

Topcon

News Flashes IGR 9-2

The World Health Organization and the United States Social Security Administration refer to blindness as a reduction of visual acuity or visual fields to a specified level in the worse eye

Even mild four to five dB differences in visual field MD were associated with a five-point difference in the Visual Function Questionnaire composite score and most subscale scores

There are observations as support for the idea that increased extracellular matrix levels are related to increased aqueous humor outflow resistance

The presence of FP receptor itself does not have any physiological effect in IOP regulation, whereas the presence of FP receptor is indispensable to lower IOP

Mechanistically, hypoxia/reoxygenation causes increased intracellular ROS-levels which induce TGF-β expression which then in turn activates αB-crystallin expression

It remains unclear if the changes in the susceptibility to optic nerve damage were or have to be caused by genetic variations or by posttranslational modifications of the correlating proteins

HRT3 may be helpful both in confirming a normal disc, by means of GPS, and in confirming a suspicion of glaucoma, by means of MRA

Structure-function associations are almost always stronger using enhanced corneal compensation compared to variable corneal compensation (VCC) (e.g., difference in R2 up to 0.22 in the inferotemporal RNFL) and structure-function associations using VCC are strengthened when scans with atypical birefringence patterns are excluded from the analyses

If regional areas of the optic nerve have similar susceptibility between the two eyes, it may help identify regions of the optic nerve that may be vulnerable to further glaucomatous injury

Medications may not protect the optic nerve from supine IOP elevations

Due to the widespread popularity and use of over-the-counter medical supplements, it is important that we understand the effects of such agents as Ginkgo biloba on ocular circulation

Marijuana lowers IOP for only 2-3 hours, making it highly impractical in most patients, and furthermore in the majority of patients the IOP-lowering effect is lost with continued dosing

A moderate effect for the peripheral vision subscale was present even for participants with moderate unilateral loss

Prevention of visual field loss, even at early stages, may be important for preserving quality of life

How can living alone be a risk factor for developing glaucoma? Are some types of glaucoma related to lifestyle?

A complex MMP-TIMP balance plays a role in ECM remodeling and consequently in the pathogenesis of glaucoma

70% of respondents felt that verifying calibration of tonometers was someone else's responsibility and they did not know how often this was being done in their clinic

Anterior segment OCT was able to identify subtle but clinically important changes in angle morphology and was capable of quantifying this

Money for diagnosis and management as well as for research is likely to be more difficult to obtain in the future unless our speciality can present cogent reasons to continue funding at present levels (Advocacy)

Atypical birefringence patterns (somewhat arbitrarily defined) are considerably less frequent using enhanced corneal compensation (ECC) compared to variable corneal compensation, indicating that the ECC technology is effective

Cellular senescence is an important part of the normal ageing process

It is surprising that increased laminin and type-IV collagen can decrease monolayer permeability and conductivity

Cellular shape changes induced by some cytoskeletal disruptive agents shifts the balance of secreted MMPs:TIMPs towards greater MMP activity

Latrunculin A and cytochalasin D affect both paracellular and extracellular matrix turnover regulatory mechanisms

Changes that occur in the lamina cribrosa of the tree shrew eye with age may have particular relevance to aging changes in the optic nerve head with regard to potential increased vulnerability to glaucomatous injury

Phenotype definitions must be very specific

While the peak 24-hour systolic blood pressure appeared consistently during evening hours for all the ages, the appearance of peak 24-hour IOP changed significantly

The theory of reduced redundency suggests that the increased sensitivity to glaucoma of function-specific tests occurs through the isolation of specific sub-populations of RGCs

It is possible that a relationship between vessel diameters and IOP develops due to age related changes

OCT and HRT are representative methods for measuring RNFL and neuroretinal rim. These observations will not necessarily translate to other technologies

SLP images with apparent Atypical Birefringence Patterns likely should not be used for glaucoma diagnosis

GDx variable corneal compensation is acceptable in the use of longitudinal assessment of the RNFL

There is certain correlation between the functional alterations detected by FDT and the structural changes detected by OCT in patients showing a normal SAP

Too often a study will conclude ocular blood flow is unaffected by a medication while using only one imaging technique or sampling in only one ocular tissue bed

Recombinant Ads are ideal to follow fluid dynamics in the TM

Issue 9-2

Table of Contents Editor's Selection

Change Issue

advertisement

WGA Rescources