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Issue 9-3
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IGR 9-3
Binocular visual function and its potential effect on quality of life in glaucoma is important
Obtaining a family history of glaucoma is highly inaccurate
Two non-synonymous SNPs of the gene lysyl oxidase like protein 1 (LOXL1) that form the major genetic component for XFS and related glaucoma were identified
Dark chocolate and omega-3-fatty acids can also improve blood flow regulation
Alterations in ECM assembly and maintenance may provide susceptibility of the optic nerve head to elevated intraocular pressure
Older GLAST deficient mice have significant loss of RGCs in the absence of elevated pressure
IOP measurements outside office hours are still very valuable since these readings may show an IOP level higher than the office-hour IOP and the peak IOP may occur frequently outside office hours
Glaucoma detection may be most effective when targeted at populations at high risk, and using a combination of evaluation methods
A comprehensive approach to ocular blood flow assessment is recommended to eliminate steal phenomenon and better represent the eye's overall vascular response to stimulus
Preservative is a necessary evil for ophthalmic solutions to avoid contamination by potentially pathogenic micro-organisms
The time to assure proper functioning of a valved or non-valved ADD is before implantation
The economic system which underpins most medical care programs appears to be based on the belief that the quality of surgery does not vary depending upon who performs it
A glaucoma-specific instrument to assess quality of life in glaucoma subjects may not need to be developed
Nearly half the items in some QOL instruments are measuring side-effects of older treatments more than patient reported symptoms of actual disease progression
LOXL1-gene variations associate with exfoliate glaucoma, but not with POAG
Have we unknowingly been harming some of our patients for decades, possibly precipitating retinal ganglion cell damage?
The gray crescent of the optic disc is a mostly unrecognised feature at the border of the optic nerve head
Ocular surface temperature is a possibly powerful, simple, comfortable, and inexpensive way to assess ocular blood flow
Avoiding intravitreal injections for drug delivery to the posterior segment may reduce significantly the risk of serious complications; drug delivery via micro needles may be carried out by non-retinal specialists
The amount of light entering the pupil should be minimized when performing gonioscopy
A screening strategy to identify and to educate family members of existing OAG patients about their greater risk of disease is feasible
If further evidence confirms that IOP spikes of 1-2 min of 50-90 mmHg induces irreversible damage, we may need to amend LASIK protocols
In the DBA/2 mouse model of glaucoma GFAP is upregulated indicating glial stress
Temporal activation of individual signaling pathways in the same eyes gives us a clue to the major pathways turned on in ganglion cells
Although CCT is important, further research is needed to clarify the role of CCT in glaucoma screening and during glaucoma treatment
Bimatoprost enhances outflow facility and hydraulic conductivity in human anterior segment organ culture and human trabecular meshwork cell monolayers
Amniotic membrane transplantation (AMT) was useful in closing conjunctival buttonholes discovered at the end of surgery after trabeculectomy with Mitomycin C
Laser irradiation of the trabecular meshwork can increase the hydraulic conductivity (HC) across the cells lining the juxtacanalicular tissue (JCT)
IOP itself, not the diurnal IOP variation, had a significant influence on the rate of glaucoma progression
The likelihood of complication was twice as great when the surgery was performed by those performing few surgeries
Successful IOP control was obtained in the majority of pediatric glaucomas at one year
The discovery of LOXL1 is extremely important
To date, none of the numerous extensive morphological and ultrastructural studies of the glaucomatous TM tissues have shown any evidence of calcification
Clinical importance of the gray crescent is that one may erroneously assume that the underlying tissue is not neuroretinal rim, but parapapillary tissue
Further analysis of the data would be needed to better delineate the role of IOP fluctuation with respect to visual field progression
Imaging is an important additional tool in the diagnosis and the management of glaucoma
CCT is a strong risk factor for the progression of ocular hypertension to glaucoma, but not at all for progression of that glaucoma nor prevalent disease
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