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Your Special Attention For IGR 9-3
Accuracy of combined GDx-VCC and matrix FDT in a glaucoma screening trial
M. Tóth, P. Kóthy, P. Vargha and G. HollóJournal of Glaucoma 2007; 16: 462-470
Abstract no. 834
"GDX-VCC and Matrix-FDT are complementary diagnostic techniques for glaucoma screening."
Corneal thickness and relating factors in a population-based study in Japan: the Tajimi study
A. Tomidokoro, M. Araie, A. Iwase; the Tajimi Study GroupAmerican Journal of Ophthalmology 2007; 144: 152-154
Abstract no. 843
"The CCT in a Japanese population was associated significantly with gender, IOP, and corneal curvature but not with age."
Aqueous humor formation and its regulation by nitric oxide: A mini review
C.W. Do, C.W. Kong, C.Y. Chan, C. Lam and C.H. ToNeuroembryology and Aging 2007; 4: 8-12
Abstract no. 853
"The nitric oxide signaling cascade is thought to regulate the ion transport across the ciliary epithelium, and thereby reduce the rate of aqueous humor formation and IOP."
Effects of refraction and axial length on childhood optic disk parameters measured by optical coherence tomography
C. Samarawickrama, X.Y. Wang, S.C. Huynh, G. Burlutsky, F. Stapleton and P. MitchellAmerican Journal of Ophthalmology 2007; 144: 459-461
Abstract no. 874
"Optic disk parameters in childhood are influenced by axial length, but not by refractive error."
CJO Lecture 2007: Central corneal thickness, tonometry, and glaucoma risk - a guide for the perplexed
J.D. BrandtCanadian Journal of Ophthalmology 2007; 42: 562-566
Abstract no. 921
"CCT is an independent predictive factor for the development of glaucoma."
Prospective study of alcohol consumption and the risk of primary open-angle glaucoma
J.H. Kang, W.C. Willett, B.A. Rosner, S.E. Hankinson and L.R. PasqualeOphthalmic Epidemiology 2007; 14: 141-147
Abstract no. 984
"Alcohol consumption did not influence the risk of POAG"
Infrared imaging technique may help demonstrate iris transillumination defects in blacks who show other pigment dispersion syndrome clinical signs
D.K. Roberts and M.N. WernickJournal of Glaucoma 2007; 16: 440-447
Abstract no. 1006
"Digital infrared iris photography may help demonstrate abnormal iris tranilllumination defects among the darkly pigmented irides of blacks."
Silicone oil pupillary block: an exception to combined argon-Nd:YAG laser iridotomy success in angle-closure glaucoma
A.H. Zalta, N.S. Boyle and A.K. ZaltaArchives of Ophthalmology 2007; 125: 883-888
Abstract no. 1028
"Irididotomy closure is not uncommon in eyes with silicone oile pupillary block glaucoma."
Optic nerve restoration: new perspectives
N.D. Bull and K.R. MartinJournal of Glaucoma 2007; 16: 506-511
Abstract no. 1064
"There is emerging interest in restoring function to the damaged glaucomatous optic nerve."
Ab interno trabeculotomy with the trabectome surgical device
S. MosaedTechniques in Ophthalmology 2007; 5: 63-66
Abstract no. 1105
"In recent experience with the ab interno trabeculotomy (Trabectome) procedure, intraocular pressure was reduced approximately 40% from baseline with a marked reduction in the need for intraocular pressure-lowering medications. No significant long-term complications were encountered. This novel technique may provide a minimally invasive surgical option for the treatment of open-angle glaucoma. Ab interno trabeculotomy (Trabectome) may provide a minimally invasive surgical option for the treatment of open-angle glaucoma."
Cost of patients with primary open-angle glaucoma: a retrospective study of commercial insurance claims data
P.P. Lee, L.A. Levin, J.G. Walt, T. Chiang, L.M. Katz, M. Dolgitser, J.J. Doyle and L.S. SternOphthalmology 2007; 114: 1241-1247
Abstract no. 1153
"There is a substantial cost burden associated with POAG."
Glaucoma in the United States and europe: predicting costs and surgical rates based upon stage of disease
P.P. Lee, S.P. Kelly, R.P. Mills, C.E. Traverso, J.G. Walt, J.J. Doyle, L.M. Katz and L.R. Siegartel; Costs of Glaucoma Study GroupJournal of Glaucoma 2007; 16: 471-478
Abstract no. 1152
"Significant potential savings and reductions in annual healthcare burden are possible if patients are diagnosed and treated at earlier stages of glaucoma."
Extra Special Attentions from IGR 9-2
Is this neuroprotective drug good for my glaucoma patients? Some key factors in clinical decision-making
Goldberg I.Canadian Journal of Ophthalmology 2007; 42: 418-420
Abstract no. 698
What will the place of neuroprotectants be in therapeutic strategies for glaucoma? This paper lays the foundation for the development of rational guidelines
Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease
Nickells RW, Schlamp CL, Li Y, Kaufman PL, Heatley G, Peterson JC, Faha B, Ver Hoeve JN.Experimental Eye Research 2007; 84: 729-736
Abstract no. 807
“Improves our understanding of the experimental monkey chronic glaucoma model”
Primary angle closure glaucoma: a developing world perspective
Thomas R, Sekhar GC, Parikh R.Clinical and Experimental Ophthalmology 2007; 35: 374-378
Abstract no. 405
An estimation of the healthcare burden of Primary Angle Closure in the developing countries
Glaucoma screening: analysis of conventional and telemedicine-friendly devices
Kumar S, Giubilato A, Morgan W, Jitskaia L, Barry C, Bulsara M, Constable IJ, Yogesan K.Clinical and Experimental Ophthalmology 2007; 35: 237-243
Abstract no. 404
In remote and rural regions, screening for glaucoma on age, family history and telemedicine-based C/D and Visual Field assessment may be more effective than IOP measurements
Should we treat the brain in glaucoma?
Gupta N, Yücel YH.Canadian Journal of Ophthalmology 2007; 42: 409-413
Abstract no. 450
As we expand our focus from IOP-lowering agents to neuroprotection, we may well find that we need to develop therapeutic strategies for the entire visual pathway.
Visual functional changes during acute elevation of intraocular pressure
Shou T.-D.Neuroscience Bulletin 2006; 22: 235-238
Abstract no. 527
A review of functional changes in the entire visual system during experimental acute IOP elevation
Progression of glaucoma associated with the sirsasana (headstand) yoga posture
Gallardo M.J, Aggarwal N, Cavanagh H.D, Whitson J.T.Advances in Therapy 2006; 23: 921-925
Abstract no. 521
Even if your patients do not practice Yoga every day, this is a reminder that there can be wide occupational or behavioural variations from the IOP values measured in a doctor's office.
The economic implications of glaucoma: A literature review
Schmier J.K, Halpern M.T, Jones M.L.PharmacoEconomics 2007; 25: 287-308
Abstract no. 809
Estimates of glaucoma-related costs and treatment cost-effectiveness vary widely between studies. Better estimates are critical for resource allocation and healthcare policy
Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
Shepard A.R, Jacobson N, Millar J.C, Pang I.-H, Steely H.T, Searby C.C, Sheffield V.C, Stone E.M, Clark A.F.Human Molecular Genetics 2007; 16: 609-617
Abstract no. 467
A molecular explanation of the pathogenic mechanisms leading from a myocillin mutation to open-angle glaucoma
Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs
Bu H.-Z, Gukasyan H.J, Goulet L, Lou X.-J, Xiang C, Koudriakova T.Current drug metabolism 2007; 8: 91-107
Abstract no. 725
A review of alternatives to the common water-based eye-drop to facilitate the formulation of less soluble, better penetrating or longer acting drugs.
From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma
Nickells RW.Canadian Journal of Ophthalmology 2007; 42: 278-287
Abstract no. 487
A review of pathogenic events leading in five stages from elevated IOP to neural tissue loss and scarring.
Ocular drug delivery: molecules, cells, and genes
Liu X, Brandt CR, Rasmussen CA, Kaufman PL.Canadian Journal of Ophthalmology 2007; 42: 447-454
Abstract no. 735
Can it be that the eye is the ideal target organ for gene and cell-based therapy?
Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis
Yam GH, Gaplovska-Kysela K, Zuber C, Roth J.Investigative Ophthalmology and Visual Science 2007; 48: 1683-1690
Abstract no. 475
We knew that mutant, misfolded myocillin was the culprit in a number of open-angle glaucoma cases. Specific, causal treatments may now be in sight for them.