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Abstract #10397 Published in IGR 6-1
Stereoscopic visual evoked potentials in normal subjects and patients with open-angle glaucomas
Bergua A; Horn FK; Martus P; Junemann AM; Korth MGraefe's Archive for Clinical and Experimental Ophthalmology 2004; 242: 197-203
PURPOSE: To evaluate stereoscopic visual evoked potentials (S-VEP) in normal controls and in patients with glaucomatous optic nerve damage. METHODS: Computer-generated dynamic random-dot stereograms were used to elicit cortical visual evoked potentials using wireless electric liquid crystal shutter glasses. Normal subjects (n = 22) and patients with glaucoma (n = 22) were investigated using five different disparities from 9-40 arc min. Statistical dependency of measurements with different stimulus at identical patients was adjusted for. RESULTS: Peak times of onset and offset response of S-VEP can be significantly delayed in glaucomas. A general linear regression model confirmed that differences between patients and normals depend on disparity. S-VEP onset shows no significant difference between controls and glaucomas at 9 arc min disparity. However, at high disparities, peak time of the onset response was significantly (p < 0.01) delayed in glaucomas when compared to normals (normals: 125.8 ± 13 msec, glaucomas: 148.2 ± 25.6 msec at 40 arc min). CONCLUSIONS: Visual evoked potential elicited by the onset of a random-dot stereogram can be used for objective measurement of stereoacuity in a clinical setting. Differences between controls and glaucomas in high and low disparities could indicate a stereo-specific deficit in glaucoma.
Dr. A. Bergua, Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany, antonio.bergua@augen.imed.uni-erlangen.de
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
