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IGR 26-1 | 2026
FI eyes demonstrated greater vulnerability to lower diastolic blood pressure compared with GE eyes, suggesting that systemic vascular factors may need to be considered in addition to IOP when managing glaucoma according to ODP subtypeEyes with inferior cMvD showed a rapid decline in both retinal sublayer thickness and vascular density, not only in the affected inferior retina but also in the unaffected superior retinaThe HMS combined with CS was a dominant strategy, offering greater benefits and lower costs compared to CS alone.Accelerated epigenetic age was strongly associated with the fast progression group, independent of IOP or baseline disease severity.This study reveals a small but statistically significant association between CCB use and a slower rate of VF deterioration, adding to the ongoing debate about their role in glaucoma.56.4% of glaucoma in the community was previously undiagnosedprogression risk of 4.4% per eye-year, more than triple the 1.3% risk seen in eyes of same baseline angle width with stable LVglaucomatous individuals experienced more pronounced IOP elevations than healthy participants, highlighting the potential risks for this vulnerable populationTrab-MMC achieved a substantially higher proportion of complete successes (IOP control without medications) at 1, 2, and 3 yearsMvD-D outperformed all other structural and vascular metrics, achieving the highest area under the curve of 0.95, and was identified in 91% of HMG patients but only 18% of HM patients.A 1-µm/year faster loss was associated with a 6-fold increase in conversion risk IGR 25-4 | 2026
Mean IOP decreased from 22.4mmHg on 2.8 medications at baseline to 14.8mmHg on 1.1 medications.Higher POAG and NTG PRSs were most strongly associated with paracentral VF loss, while higher HTG genetic risk correlated with total VF loss but not paracentral defectsAfter a mean follow-up of 35.8 months, IOP was reduced to 12.2 mmHg on 1.1 medications, with qualified success reached in 92% of uveitic eyes treated with the PAUL Glaucoma Implant.Retinal vasculometry, if standardized across platforms and populations, could emerge as a scalable biomarker for both ocular and systemic vascular disease surveillance.Incomplete reporting is pervasive among 969 glaucoma trials identified with limited search terms with only 53% published, and 32% provided results on ClinicalTrials.govOnly about 1.3% of the variability in IOP can be explained by AP, emphasizing its minor practical impact in ordinary conditionssemi-annual testing may optimize resource utilization and reduces healthcare burdens while maintaining the ability to identify clinically significant progression60-4 visual field testing was much more likely to capture visual defects in eyes with mild disease (sensitivity=87%) as compared to algorithms testing the more central visual field (30-2: 50%; 10-2: 15%).some participants received topical beta-blockers in the non-study eye which may have contributed to study-eye IOP reductions via the contralateral crossover effectFrontloading offers a pragmatic way to increase usable perimetric information and improve signal-to-noise for detecting progression, potentially allowing services to meet minimum testing targets without adding visits.the glaucoma–sleep disorder "association" may be partly due to differential surveillance rather than true excess disease IGR 25-3 | 2025
sustained intraocular pressure (IOP) reduction from a baseline of 28.8 mmHg to 15.8 mmHg (reduction of 42.6%), with a concomitant decrease from 1.9 to 0.8 medication types per eyeAn active PA index category and a higher PA amount were associated with a slower rate of VF mean deviation (MD) loss in univariable analysisContrary to most prior observational studies, they conclude that thicker central corneas increase POAG liabilitythe risk ratio for developing glaucoma was 50.4% and 58.5%, respectively, indicating a 2-fold lower risk of developing POAG for those using GLP-1 drugs versus other weight loss therapiesThis exemplifies the scarcity of population-based datasets on the prevalence of glaucoma in Africa in the last 2 decades, and still no sources from North and Central Africa.portable perimetry could provide reliable data that independently or in combination with clinic-based current reference standard devices, was able to detect progression earlier then this may have significant benefits for glaucoma caresupplementation with these cofactors conferred robust structural and functional neuroprotection in both acute and chronic ocular hypertension models underpinning good potential for translation to glaucoma patientsantagonistic interactions were observed between prostaglandin F2α analog and beta-adrenergic blockers or Rho-associated protein kinase inhibitorsHPV infection was associated with a ~30 to ~60% increased risk of glaucoma (OAG, ACG, or both), depending on the models used.The SIBS microshunt group demonstrated the best postoperative outcomes, with 69% achieving complete surgical success (medication-free IOP of 17 or less with no visually significant hypotony and reduction in IOP of at least 20%) as compared to 58% and 46%a 1 SD increment in grip strength was associated with a 17% lower likelihood of prevalent glaucoma, and a <0.2 µm increment in macular GCIPL thicknessearly functional decline may forecast long-term progression even in earlier disease stages IGR 25-2 | 2025
Both low MAP and DAP, when combined with low mean IOP and increased SD, also resulted in steeper MD slopesThe use of portable visual field devices such as virtual reality headsets is still in its infancy and there are presently a wide variety of approaches that are being employed, none of which have been able to achieve the highest degree of compatibility with the methods employed by the Humphrey Field AnalyzerIf the results of this pilot study are confirmed, the oxygen consumption of peripheral mononuclear blood cells and the nicotinamide adenine dinucleotide level may become new biomarkers for progressive glaucomaThis study highlights the importance of separating POAG genetics into IOP-dependent and IOP-independent componentsDespite greater access to eye care, PACG prevalence was similar to that reported in China, and visual morbidity was strikingly low: only one case of unilateral blindness and none of bilateral blindness, even though three-quarters of PACG cases were previously undiagnosed.Its clinical relevance remains uncertain, as the role of IOP fluctuation in glaucoma progression is still debated, and recent evidence does not consistently support diurnal or long-term IOP variability as independent predictors of disease progression.Switching to SLT decreased medication use significantly (from 1.38 to 0.59 mean medications) and allowed 60.5% to attain medication freedom.IOP measurements obtained by Tono-Vera and ORA were comparable to each other, among patients with and without open angle glaucoma IGR 25-1 | 2025
Reduced diagnostic sensitivity of RNFLT measurements in individuals of African descentROTA as a promising tool for identifying early macular damageDeveloping ophthalmology-specific LLM-based systems to maximize predictive performanceCan vision be recovered in glaucoma?“….healthy contralateral eyes in patients with unilateral NTG are at significant risk of structural progression. As such, prophylactic treatment should be considered for these eyes”These results underscore the need for clinicians to incorporate axial length differences in their interpretation of structural and functional glaucoma metrics IGR 24-4 | 2024
The sequence of damage remains unknown for now: whether distal AHO pathway
changes are due to primary dysgenesis of the vessels or high IOP vessel collapse
from lack of flow that subsequently could be rescued laterTheir results shine a powerful spotlight on the innovation and utility of modulating
intracellular astrocyte signalling cascades using gene therapy for patient-specific
interventions tailored to key points in progressionBrowse
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