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Abstract #10896 Published in IGR 6-2
Short-term hypotensive effect of additional brinzolamide in glaucoma treatment
Wada S-A; Inoue K; Wakakura M; Inouye J; Tomita GJapanese Journal of Clinical Ophthalmology 2004; 58: 931-935
We evaluated the hypotensive effect of brinzolamide in 142 eyes of 85 glaucoma patients as added to prior topical medications. The series comprised primary open-angle glaucoma 75 eyes, normal-tension glaucoma 48 eyes, and other glaucoma entities 19 eyes. Before start of brinzolamide, 32 eyes and been receiving one medication and 110 eyes had been receiving two or more medications. The baseline intraocular pressure (IOP) averaged 17.4± 3.1 mmHg in the whole series. After start of 1% brinzolamide twice daily, the IOP averaged 15.0±2.9 mmHg one month later, 14.9±2.9 mmHg 2 months later, and 14.9±2.9 mmHg 3 months later. Each value was significantly lower than the baseline IOP (p<0.0001). During the 3-month treatment, the IOP decreased significantly than the baseline value in primary open-angle glaucoma, normal-tension glaucoma, and other glaucoma entities (p<0.0001). Minor adverse effect developed in 8 eyes (9%). It is concluded that additional brinzolamide is safe and effective for various types of glaucoma. LA: Japanese
S.-A. Wada, Inouye Eye Hospital, 4-3 Kanda-Surugadai, Chiyoda Tokyo 101-0062
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)