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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (0)   1.3 Pathogenesis (4)   1.4 Quality of life (6)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (3) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (3)   2.2 Cornea (5)   2.3 Sclera (2)   2.4 Anterior chamber angle (2)   2.5 Meshwork (1)     2.5.1 Trabecular meshwork (8)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (2)     2.6.2 Outflow (4)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (1)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (11)   2.14 Optic disc (9)   2.15 Optic nerve (4)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (10)   3.1 Microscopy (1)   3.2 Electron microscopy (5)   3.3 Immunohistochemistry (9)   3.4 Molecular genetics (1)     3.4.1 Linkage studies (16)     3.4.2 Gene studies (2)   3.5 Molecular biology incl. 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Abstract #11451 Published in IGR 6-3

Intraobserver variability in optical coherence tomography

Browning DJ; Fraser CM
American Journal of Ophthalmology 2004; 138: 477-479

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PURPOSE: To assess the intraobserver variability of optical coherence tomography (OCT) in patients with clinically stable maculas. DESIGN: Retrospective, observational case series using a diagnostic instrument. METHODS: Retrospective study. Setting. Private retina practice. Patient population. Twenty-two eyes of 19 patients, each studied twice within 4 months. observation procedure. Optical coherence tomograph measurements of the macula obtained by two photographers. MAIN OUTCOME MEASURES: Ordinary least products (OLP) and Bland-Altman analysis of OCT data. RESULTS: No fixed or proportional bias was detected in foveal zone thickness and total macular volume between measurements of either of the OCT operators. The coefficient of repeatability for foveal zone thickness was 37.0 μm for photographer 1 and 34.8 μm for photographer 2. The coefficient of repeatability for total macular volume was 0.29 mm₃ for photographer 1 and 0.10 mm₃ for photographer 2. CONCLUSION: Foveal zone thickness and total macular volume measurements show low intraobserver variability when analyzed by OLP and Bland-Altman techniques. Bounds are given for foveal zone thickness and total macular volume for which longitudinal OCT measurements by the same operator can be considered to reflect natural history or intervention effects rather than intraobserver variability.

Dr. D.J. Browning, Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, NC 28210, USA. djbrowning@carolina.rr.com

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Classification:

6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)

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