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Abstract #126730 Published in IGR 25-2
Cognitive Impairment in Primary Open Angle Glaucoma: A Case-Control Study
Garg M; Midha N; Verma R; Gupta V; Angmo D; Velpandian T; Maharana PK; Satapathy S; Sharma N; Dada TJournal of Glaucoma 2025; 34: 282-289
PRCIS: Cognitive impairment in multiple domains was observed in primary open angle glaucoma patients as compared with age and gender-matched healthy controls. OBJECTIVE: Evaluation of cognitive impairment in individuals with primary open angle glaucoma (POAG). METHODS: In this case-control study, individuals with POAG (cases, n=70) were compared with age-matched and sex-matched healthy individuals (controls, n=70) using detailed ophthalmological evaluation, cognitive assessment, and serum cortisol level. A multitude of tests were employed to comprehensively assess various domains of cognitive function: Addenbrooke Cognitive Examination (ACE-III; attention/orientation, memory, language, verbal fluency, and visuospatial skills), Postgraduate Institute Memory Scale (PGIMS; verbal and nonverbal memory), Wisconsin Card Sorting Test (WCST; nonverbal executive functions), Go No-Go task (GNG; inhibitory control), and Trail Making Test (TMT; attention and working memory). RESULTS: Intraocular pressure and cup disc ratio were significantly higher ( P <0.001), while retinal nerve fiber layer (RNFL) thickness and mean deviation were significantly lower in cases as compared with controls. Cases had significantly lower scores on ACE-III and PGIMS ( P <0.001) and longer test completion time in TMT-A ( P =0.001). The performance of cases was also significantly worse on most parameters of the WCST and GNG tasks. Serum cortisol level was significantly higher in cases (11.75±7.41 mcg/dL) compared with controls (7.93±2.39 mcg/dL; P =0.02). A significant correlation was observed between serum cortisol level and WCST correct response ( P =0.04), WCST error response ( P =0.002), and total time taken in TMT-A ( P =0.03). Visual field mean deviation also exhibited a significant correlation with serum cortisol level ( P <0.001) and total time taken on WCST ( P =0.03) and TMT-A ( P =0.03). CONCLUSIONS: Individuals with POAG exhibited higher cognitive impairment and raised serum cortisol levels than age-matched healthy controls. Early recognition and management of cognitive impairment are pivotal for enhancing the quality of life and implementing comprehensive glaucoma care.
Dr. Rajendra Prasad Centre for Ophthalmic Sciences.
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