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Abstract #128785 Published in IGR 25-3
PEST-containing nuclear protein in eye health and disease: A review
Hussain W; Jiang ZL; Liu Y; Wang JY; Yasoob TB; Hussain SA; Laila UE; Wu DD; Ji XY; Dang YLExperimental Eye Research 2025; 258: 110451
The human visual system plays a crucial role in how we perceive the world. However, it is susceptible to ocular conditions that can result in visual impairments. Globally, over 2.2 billion people suffer from vision impairments, including macular degeneration, refractive errors, cataracts, and glaucoma. In the field of iridology and ocular biology, essential proteins governing ocular homeostasis are frequently mutated or dysregulated. Clear vision is essential for people, and mutations related to these proteins can significantly impact the prevalence and progression of eye disorders. This review discusses proteins linked to ocular disorders, including the nuclear protein Ras, the human ER1 protein, and the PEST-containing nuclear protein (PCNP). Identifying and studying potential therapeutic targets and strategies to regulate these proteins is crucial for minimizing the burden of eye disorders. PCNP has been specifically linked to the development of several eye disorders. An understanding of these molecular processes will facilitate the development of clinical strategies to treat ocular disorders effectively. The main focus of this review is PCNP because of its significant role in the pathophysiology of eye disorders. Dysregulation of this protein has been linked to several ocular diseases, highlighting the need to clarify its functions. A comprehensive understanding of these essential proteins is vital for developing effective treatments and preventive measures against ocular pathologies. This review aims to advance global research, treatment, and management of preventable blindness and vision impairment by exploring strategies to target and regulate these potential therapeutic candidates.
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Department of Oncology, Huaxian County Hospital, Anyang, Henan, 456400, China.
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