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Abstract #17636 Published in IGR 9-2
Matrix-metalloproteinases and glaucoma
Malcea C; Stefan COftalmologia 2006; 50: 77-81
PURPOSE: To analyze the matrix-metalloproteinases' activity (MMP-2 and MMP-9) in primary open angle glaucoma patients with indication for filtrating surgery. METHODS: A prospective study, 8 months, in the Ophthalmology Department of the Central Military Hospital, with the collaboration of the 'Victor Babes' Institute. The study was conducted on 27 eyes with primary open glaucoma and that have underwent filtrating surgery. Patients with other ocular or systemic associated conditions were excluded. Patients were distributed in 3 groups, according to their topical treatment with prostaglandin analogs: Group A: 11 eyes with travoprost 0,004%. Group B: 9 eyes with latanoprost 0,005%. Group C: 7 eyes without prostaglandin analogs. The fragments collected during surgery were processed for imunohistochimical analysis for MMPs. It has used the indirect tristadial method: streptavidine-biotin-peroxidase. LA: Romanian
Dr. C. Malcea, Sectia Clinica de Oftalmologie, Spitalul clinic de Urgenta Militar Central, Rumania
Classification:
3.9 Pathophysiology (Part of: 3 Laboratory methods)