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Abstract #27450 Published in IGR 12-4
The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population
Khan MI; Micheal S; Akhtar F; Ahmed W; Ijaz B; Ahmed A; Qamar RMolecular Vision 2010; 16: 2146-2152
Purpose: The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients. Methods: Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls. Results: In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (X(2)=21.82, p<0.001). This association was specifically related to the female patients (X(2)=35.63, p<0.001); no such association was seen in the male patients (X(2)=2.28, p>0.05). Conclusions: The results suggest that there is a significant involvement of the GSTT1 and GSTM1 polymorphisms in female Pakistani patients having PEXG, which suggests a possible gender-specific impairment of detoxification in this group. (copyright) 2010 Molecular Vision.
R. Qamar. Faculty of Science, COMSATS Institute of Information Technology, Park Road, Islamabad-45600, Pakistan. raheelqamar@hotmail.com
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
9.4.3.1 Pigmentary glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.3 Glaucomas associated with disorders of the iris and ciliary body)
