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Abstract #27908 Published in IGR 13-1

Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma

Ly T; Gupta N; Weinreb RN; Kaufman PL; Yucel YH
Vision Research 2011; 51: 243-250

See also comment(s) by Ronald Harwerth •

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Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions

Y.H. Yucel. Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. yeni.yucel@utoronto.ca

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Classification:

5.2 Primates (Part of: 5 Experimental glaucoma; animal models)
2.16 Chiasma and retrochiasmal central nervous system (Part of: 2 Anatomical structures in glaucoma)

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