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Abstract #27925 Published in IGR 13-1

The concave iris in pigment dispersion syndrome

Liu L; Ong EL; Crowston J
Ophthalmology 2011; 118: 66-70

See also comment(s) by Jeffrey Liebmann •

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Objective: To visualize the changes of the iris contour in patients with pigment dispersion syndrome after blinking, accommodation, and pharmacologic miosis using anterior segment optical coherence tomography. Design: Observational case series. Participants: A total of 33 eyes of 20 patients with pigment dispersion syndrome. Methods: Each eye was imaged along the horizontal 0- to 180-degree meridian using the Visante Anterior Segment Imaging System (Carl Zeiss Meditec, Dublin, CA). Scans were performed at baseline and after focusing on an internal fixation target for 5 minutes, forced blinking, accommodation, and pharmacologic miosis with pilocarpine 2%. Main Outcome Measures: Quantitative analysis of the changes in the iris configuration. Results: After 5 minutes of continual fixation, the iris became planar with the mean (plus or minus) standard deviation curvature decreasing from 214(plus or minus)74 (mu)m to 67(plus or minus)76 (mu)m (P<0.05). The iris remained planar in all patients with pigment dispersion syndrome after forced blinking, but the iris concavity recovered to 227(plus or minus)113 (mu)m (P = 0.34) and 238(plus or minus)119 (mu)m (P = 0.19) with the -3.0 and -6.0 diopter lenses, respectively. Pilocarpine-induced miosis caused the iris to assume a planar configuration in all subjects. Conclusions: This study shows that the iris in pigment dispersion syndrome assumes a planar configuration when fixating and that the concavity of the iris surface is not restored by blinking. Accommodation restored the iris concavity, suggesting that the posterior curvature of the iris in pigment dispersion syndrome is induced and probably maintained, at least in part, by accommodation.

L. Liu. FRANZCO, Preston Eye Clinic, 268 Murray Road, Preston VIC 3072, Australia. drlsliu@hotmail.com

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Classification:

9.4.3.1 Pigmentary glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.3 Glaucomas associated with disorders of the iris and ciliary body)
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)

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