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Abstract #27954 Published in IGR 13-1
Drug delivery to the posterior segment of the eye
Kuppermann BD; Loewenstein ADevelopments in Ophthalmology 2010; 47: 59-72
Drug delivery into the posterior segment of the eye is complicated by the existence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the barrier, and local drug delivery (including transcorneal, transscleral, and intravitreal). Recently, new topical treatments have emerged for the treatment of posterior eye disease. Iontophoretic, juxtascleral, and intravitreal routes can be used to achieve therapeutic levels in the posterior segment. Extended-release intravitreal drug delivery systems can achieve sustained therapeutic levels with the goal of providing a prolonged clinical benefit.
A. Loewenstein. Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv University, 6 Weizmann St., Tel Aviv 64239, Israel. anatl@tasmc.health.gov.il
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)