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Abstract #45769 Published in IGR 13-2
Choroidal Thickness Measured by Spectral Domain Optical Coherence Tomography. Factors Affecting Thickness in Glaucoma Patients
Maul EA; Friedman DS; Chang DS; Boland MV; Ramulu PY; Jampel HD; Quigley HAOphthalmology 2011;
Purpose: To measure choroidal thickness and to determine parameters associated with it. Design: Cross-sectional study. Participants: Seventy-four glaucoma patients and glaucoma suspects. Methods: Spectral domain optical coherence tomography (SD-OCT) scans were obtained to estimate average choroidal thickness in a group of glaucoma suspects and glaucoma patients. The average thickness was calculated from enhanced depth SD-OCT images and manually analyzed with Image J software. Open-angle glaucoma, open-angle glaucoma suspect, primary angle-closure glaucoma, primary angle closure, and primary angle-closure suspect were defined by published criteria. Glaucoma suspects had normal visual fields bilaterally. Glaucoma was defined by specific criteria for optic disc damage and visual field loss in (greater-than or equal to)1 eye. The most affected eye was analyzed for comparisons across individuals, and right/left and upper half/lower half comparisons were made to compare thickness against degree of visual field damage. Main Outcome Measures: Average macular and peripapillary choroidal thickness measured using SD-OCT. Results: The choroidal-scleral interface was visualized in 86% and 96% of the macular and peripapillary scans, respectively. In multivariable linear regression analysis, the macular choroid was significantly thinner in association with 4 features: Longer eyes (22 (mu)m per mm longer [95% confidence interval (CI), -33, -11]), older individuals (31 (mu)m thinner per decade older [95% CI, -44, -17]), lower diastolic ocular perfusion pressure (26 (mu)m thinner per 10 mmHg lower [95% CI, 8, 44]), and thicker central corneas (6 (mu)m per 10 (mu)m thicker cornea [95% CI, -10, 0]). The choroid was not significantly thinner in glaucoma patients than in suspects (14 (mu)m [95% CI, -54, 26]; P = 0.5). Peripapillary choroidal thickness was not significantly different between glaucoma and suspect patients. Thickness was not associated with damage severity as estimated by visual field mean deviation or nerve fiber layer thickness, including comparisons of right with left eye or upper with lower values. Conclusions: Age, axial length, CCT, and diastolic ocular perfusion pressure are significantly associated with choroidal thickness in glaucoma suspects and glaucoma patients. Degree of glaucoma damage was not consistently associated with choroidal thickness.
E.A. Maul. The Glaucoma Service and Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute at Johns, . Email: emaul@jhsph.edu
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
