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Abstract #73302 Published in IGR 18-4
Social, health and ocular factors associated with primary open angle glaucoma amongst Chinese Singaporeans
Chiam N; Baskaran M; Li Z; Perera S; Goh D; Husain R; Khor CC; Cheng CY; FRCOphth TA; Vithana ENClinical and Experimental Ophthalmology 2018; 46: 25-34
IMPORTANCE: There is limited literature on the association of lifestyle and health factors related to primary open angle glaucoma amongst Asians. BACKGROUND: This study evaluated the association of primary open angle glaucoma with smoking, health and ocular factors among Chinese Singaporeans. DESIGN: Case-control study PARTICIPANTS: 711 primary open angle glaucoma patients from a Singapore hospital and 2788 population-based controls. METHODS: Subjects underwent clinical examination and completed a questionnaire with details on family history of glaucoma, comorbidities, smoking, alcohol consumption, age at menopause and use of hormone replacement therapy. Primary open angle glaucoma was sub-classified as normal-tension glaucoma and high-tension glaucoma depending on the untreated intraocular pressures. MAIN OUTCOME MEASURES: Association between ocular, health and lifestyle factors, with normal-tension and high-tension glaucoma. RESULTS: Using multiple logistic regression, primary open angle glaucoma was associated with older age (OR 1.12 per year older; 95% CI 1.10-1.15; p<0.001), family history of glaucoma (OR 7.86; 95% CI 4.48-13.79; p<0.001), higher intraocular pressure (OR 1.75 per 1 mmHg; 95% CI 1.64-1.87; p<0.001) and thinner central corneal thickness (OR 1.01; 95% CI 1.01-1.02; p<0.001). Myopes were more likely to have primary open angle glaucoma (p<0.001). A current smoking habit was protective against normal-tension glaucoma (OR 0.30; 95% CI 0.10-0.92; p=0.035). Patients with normal-tension (versus high-tension glaucoma) were more likely to be females (OR 4.50; 95% CI 1.58-12.82; p=0.005). CONCLUSIONS AND RELEVANCE: Older age, family history of glaucoma, higher intraocular pressure, thinner central corneal thickness and myopia were significantly associated with primary open angle glaucoma among Chinese Singaporeans.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
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