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Abstract #73534 Published in IGR 18-4
Detection of functional change in preperimetric and perimetric glaucoma using 10-2 Matrix Perimetry
Jung KI; Park CKAmerican Journal of Ophthalmology 2017; 182: 35-44
PURPOSE: To evaluate an effective functional strategy for detecting glaucomatous damage of the macula in preperimetric to perimetric glaucoma DESIGN: Cross-sectional study METHODS: Preperimetric glaucoma patients (n=102) and perimetric glaucoma patients (n=88) with isolated paracentral scotoma or combined paracentral scotoma were enrolled in this study. Global and sectoral mean sensitivities (MS) were evaluated using 10-2 standard automated perimetry (SAP) with a stimulus of sizes III (0.43° diameter), V (1.72°), and 10-2 matrix perimetry with a stimulus of 2°. Ganglion cell-inner plexiform layer (GCIPL) was measured using spectral domain optical coherence tomography. RESULTS: The percentage of significantly depressed VF points < 5% and < 1% in the pattern deviation plot was higher with FDT 10-2 than with SAP 10-2 III in patients with preperimetric glaucoma (both P<0.001). Using FDT 10-2 tests, the structure-function correlation was superior to SAP 10-2 (III or V) both in preperimetric and perimetric glaucoma. Topographic structure-function relationships for each VF test were more favorable with the FDT 10-2 test. The preperimetric glaucoma patients showing VF abnormalities on FDT 10-2 or SAP 10-2 (III) showed thinner average, minimum, superior, inferior and inferotemporal GCIPL thicknesses than in those without VF abnormalities (all P<0.05). CONCLUSIONS: FDT 10-2 was found to detect functional damage of the macula early in preperimetric glaucoma, and perform better than with SAP 10-2 (size III or V) from preperimetric to perimetric glaucoma in the structure-function relationship. FDT 10-2 can be considered a useful tool to detect glaucomatous damage of the macula early and appropriately.
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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