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Abstract #15044 Published in IGR 8-4
Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study
de Voogd S; Ikram MK; Wolfs RC; Jansonius NM; Witteman JC; Hofman A; De Jong PTOphthalmology 2006; 113: 1827-1831
See also comment(s) by David Friedman •
PURPOSE: To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG). DESIGN: Prospective population-based cohort study. PARTICIPANTS: Participants aged ≥ 55 years from the Rotterdam Study, The Netherlands. METHODS: Participants at risk for incident OAG (iOAG) underwent at baseline (1990-1993) and follow-up (1997-1999) the same ophthalmic examination including intraocular pressure (IOP) measurement, visual field testing, and simultaneous stereo optic disc photography. At baseline, diabetes mellitus was defined as the use of antidiabetic medication and/or a random or postload glucose value ≥ 11.1 mmol/l. The diagnosis of OAG was made with an algorithm based on optic disc measures and visual fields, independent of the IOP. MAIN OUTCOME MEASURE: Incident OAG. RESULTS: In total, 3837 participants without OAG at baseline were reexamined. After a mean follow-up time of 6.5 years, iOAG developed in 87 persons. The relative risk of iOAG associated with baseline diabetes was 0.82 (0.33-2.05). After adjustment for age, gender, follow-up time, IOP, IOP-lowering treatment, body mass index, and systemic hypertension, the relative risk of iOAG was 0.65 (0.25-1.64). CONCLUSIONS: In this prospective population-based study, diabetes mellitus was not a risk factor for OAG.
Dr. S. De Voogd, Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
1.1 Epidemiology (Part of: 1 General aspects)
