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Abstract #12077 Published in IGR 7-1
Significance of second-order kernel of mfERG in the diagnosis of open angle glaucoma
Yu X; Lin B; Zhu X; Yang A; Xing YChinese Ophthalmic Research 2005; 23: 75-78
OBJECTIVE: To study and evaluate the significance of second-order kernel (SOK) of multifocal electroretinogram (mfERG) in the diagnosis of primary open angle glaucoma (POAG). METHODS: mfERG were recorded on 48 eyes of 24 normal controls and 78 eyes of 45 patients with early, advanced and late stages of POAG. The response densities and latencies of P1 wave from 5 rings and 4 quadrants were analyzed. RESULTS: In the normal controls, the response densities of P1 wave was reduced with the increase of eccentricity among 5 rings (F = 189.00, P < 0.01), and the difference in the response densities was not statistically significant among 4 quadrants. The response density at the 1st, 2nd and 4th quadrant was significantly lower in the early stage of POAG and was generally suppressed in all the rings and quadrants in the advanced and late stage of POAG (P < 0.05). Significant difference in response densities could be found among different stages of POAG from every ring and quadrant (P < 0.05), and there was no remarkable changes in latencies between POAG and normal eye as well as among various stages of POAG. The sensitivity of SOK in different stage of POAG was 74.19%, 88.0% and 100% respectively and the specificity 79.17%. CONCLUSION: SOK exhibits different feature for every stage of POAG, and it is an useful tool for the diagnosis of POAG. LA: Chinese
Dr. X. Yu, Department of Ophthalmology, People's Hospital of Zhongshan City, Zhongshan 528403, China
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)