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Abstract #51730 Published in IGR 14-4
Immune regulation toward immunomodulation for neuroprotection in glaucoma
Tezel GCurrent opinion in pharmacology 2013; 13: 23-31
Although the immune system functions to preserve and restore tissue homeostasis, accumulating risk factors, prolonged glial activation, and sustained release of pro-inflammatory mediators in glaucoma may lead to a failure in the regulation of stress-induced immune response, and innate immune cells, autoreactive T cells, autoantibodies, and excess complement attack may exhibit potent stimuli that harm retinal ganglion cell somas, axons, and synapses. Identification of the cellular and molecular components of immune response pathways can provide immunomodulatory treatment strategies to attenuate neuroinflammation, protect neural tissue from collateral injury, and enhance endogenous recovery processes. This review highlights the current knowledge of molecular mechanisms regulating neuroinflammation in glaucoma.
Departments of Ophthalmology & Visual Sciences and Anatomical Sciences & Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA. gulgun.tezel@louisville.edu
Full articleClassification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
3.10 Immunobiology (Part of: 3 Laboratory methods)
