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Abstract #49263 Published in IGR 14-1
A Validated Risk Calculator to Assess Risk and Rate of Visual Field Progression in Treated Glaucoma Patients
De Moraes CG; Sehi M; Greenfield DS; Chung YS; Ritch R; Liebmann JMInvestigative Ophthalmology and Visual Science 2012; 53: 2702-2707
PURPOSE: To develop and validate a model to predict visual field (VF) outcomes in patients with treated glaucoma. METHODS: Data from 587 eyes with treated glaucoma evaluated in a cohort were used to develop two equations to predict VF outcomes, one estimating the risk of progression (%) and another estimating the global rate of VF sensitivity change (dB/yr). These equations, which included variables associated with VF progression in a multivariable model, were then tested in another cohort (n= 62 eyes) followed for at least 4 years. Agreement, discrimination, and calibration of the model in the validation sample were assessed as main outcome measures. RESULTS: The mean difference between observed and predicted global rates of sensitivity change was 0.13 dB/yr (95% CI= 0.06 to 0.18 dB/yr) and the mean difference between observed and predicted final VF MD values was 0.37 dB (95% CI= 0.00 to 0.75 dB). The predictive model had moderate discriminative ability to estimate VF progression in the independent sample (c-index of 0.78, 95% CI = 0.59 to 0.97). CONCLUSIONS: This is the first attempt to generate and validate a risk model for patients with treated glaucoma. The prediction model showed moderate accuracy in estimating future VF outcomes in an independent glaucoma population and may be useful for the objective assessment of risk of progressive VF loss.
Ophthalmology, New York Eye and Ear Infirmary, 310 E 14th St, New York, NY, USA.
Full articleClassification:
6.20 Progression (Part of: 6 Clinical examination methods)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)