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Editors Selection IGR 11-2

Intraocular Pressure and Outflow: Diurnal IOP curve versus poor-man's curve

Comment by Tony Realini on:

26291 Comparing the measurement of diurnal fluctuations in intraocular pressure in the same day versus over different days in glaucoma, Magacho L; Toscano DA; Freire G et al., European Journal of Ophthalmology, 2010; 20: 542-545

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Magacho et al. (667) obtained a one-day diurnal IOP curve on 25 patients with primary open-angle glaucoma, then followed that with a poor-man's diurnal curve in which IOP at each time point was measured on separate days three to seven days apart. They asked the question: can a reconstructed diurnal IOP curve provide comparable information to a one-day diurnal curve? This is a practical question: in patients whom we've seen many times in the past, can we construct a diurnal curve from a series of single time point measurements taken over multiple past visits? In their study, all of the key diurnal IOP parameters ‐ peak IOP, trough IOP, and range of IOP ‐ were all statistically similar and highly correlated between the one-day and multi-day IOP curves. These findings suggest that the poor-man's diurnal curve is an acceptable compromise given the cost and convenience limitations of obtaining one-day diurnal curves. The investigators also point out that a multiday IOP curve may be more representative of true IOP behavior, as it captures the effects of day-to-day variability in diet, activity, and other factors that likely play a role in determining IOP.

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