Makoto Araie

• By analyzing intraocular pressure (IOP) readings with Goldmann applanation tonometer in 7313 normal Japanese in Tajimi city, the IOP tends to be higher in those with thicker cornea, smaller corneal curvature, more myopic, younger age, higher systolic blood pressure, and higher body mass index.
• In 11 eyes, of those in whom triamcinolone 10 mg was applied at the end of vitreous surgery, 4 eyes showed intraocular pressures higher than 21 mmHg at longer than 6 months after surgery, and 2 showed higher than 21 mmHg even with glaucoma medication at longer than 24 months after surgery, whereas those received 5mg triamcinolone did not mark high intraocular pressure after 6 months.
• Regardless of existence of glaucoma, eyes with exfoliation material had less corneal endothelium than those with primary open-angle glaucoma or the normal eyes did.
• In normal-tension glaucoma patients with systemic hypertension, those treated with oral angiotension converting enzyme (ACE) inhibitor, which increases nitric oxide via bradykinin, kept visual field defects stable for more than 2 years (MD slope = +0.48 dB/year) comparing to those treated with other than ACE inhibitor (MD slope = -0.49 dB/year) by retrospective analyses.
• In mouse fibroblast, exogenous TNF a suppressed fibrilization derived by TGF-b1, while endogenous TNF a in fibroblast did not have influence on fibrilization. In a tissue fibrilization, TNF a from macrophage seems to have a significant role.
• In a case control study, A-110C polymorphism of Heat Shock Protein 70-1 showed a higher frequency of AA type in glaucoma patients than in normal control subjects (p = 0.007), while no such a difference was observed in G+190C polymorphism.
• In prostanoid FP receptor knock out mouse, travoprost, bimatoprost, unoproston, tafluprost, as well as latanoprost did not show intraocular pressure lowering effects, while bunazosine chloride reduced the intraocular pressure significantly.
• In patients with ischemic optic neuropathy in only one eye, the cup volume and the cup depth measured by a Heidelberg Retina Tomograph did not show significant differences comparing with the contralateral normal eye, whereas the cup to disc area ratio, the rim volume and the cup shape measure showed significant differences between the affected and unaffected eyes. Retinal nerve fiber layer thickness by a GDx was significantly reduced in the affected eye.
• Comparing viscocanalostomy in glaucoma triple procedure with trabeculotomy in glaucoma triple procedure, the reduction rate of intraocular pressure was higher in viscocanalostomy triple after 5 years and side effects were less frequent. (3-048 p158)
• In selective laser trabeculoplasty, 50 % survival period was 2.0 months when an increase of out-flow pressure by 30% or more was considered to be a success. The 5-year survival rate was 0.39.

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