Goldmann applanation tonometers should be re-calibrated regularly,
emphasized by a prospective study of 50 tonometers indicating that 72%
of instruments in an academic center did not meet the manufacturer's
recommendation.
abnormal tau protein associated with Alzheimer's disease is also
present in post-mortem human glaucoma eyes with a history of elevated
intraocular pressure and optic nerve head excavation, suggesting a role
for abnormal tau in glaucomatous degeneration.
Independent mechanisms may underlie peripapillary atrophy and disc
change in glaucoma patients, a longitudinal study suggests after failing
to demonstrate a relationship between peripapillary atrophy and extent
or rate of disc change.
Glutamate appears involved in glaucomatous CNS degeneration in monkey, with increased NMDA R1 glutamate receptor in
lateral geniculate nucleus layers connected to the glaucoma eye.
Retinal nerve fiber layer measured by optical computed tomography (OCTIII)
seems minimally affected by anatomic variations in optic disc area,
axial length and refractive error in one glaucoma screening study.
In combination with the comprehensive clinical evaluation of the
glaucoma patient, HRT evaluation provides optic nerve head information
that can help to diagnose and/or monitor glaucomatous disease.
The self reported prevalence of glaucoma in Canada increases with age,
and is approx. 11% in the over 80 years age group.
Barriers to managing glaucoma effectively such as non-compliance and
ineffective medication administration were reported at 33% and 49% of
glaucoma patients (n = 80) respectively at one institution.
The recent significant increase in the number of laser trabeculoplasties performed in Ontario from 2002-2004 (230% increase) coincides
with the introduction of selective laser trabeculoplasty.
Changing the classification of angle closure glaucoma may be necessary
for a better understanding of disease and to help design studies to
determine optimal management strategies.
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