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News Flashes IGR 6-1

By the year 2020, the number of people suffering from OAG in the USA will have increased from two million to more than three million

Pseudoexfoliation is rare in China

A culture model for Schlemm's canal endothelium was created

Neuroprotection of retinal ganglion cells via the opening of mitochondrial ATP-sensitive potassium channels is a completely novel mechanism

The endothelin-1 induced rodent optic neuropathy model demonstrates a time dependent loss of RGS from bloodflow reduction

Enlargement of peripapillary atrophy is not a frequent sign in progressive glaucoma

By gonioscopy, six percent of the study population had Shaffer grade two or less, with nearly twice as many found to have an angle width of less than twenty degrees when using the UBM

The suggestion that XFS patients suffer from a multitude of vascular or non-vascular disorders does not carry, as yet, much biological plausibility

Because tonometry only estimates anterior chamber pressure, the presence of a trans-iris pressure differential suggests a further source of error in estimating 'true' IOP at the optic nerve head

It is suggested that moderate to high-risk individuals with OHT be seen annually or semi-annually, have adequate high-quality baseline documentation of their optic nerve and visual fields, and that both the patient and the physician have an obligation not to miss follow-up evaluations

The incidence of iridial pigmentation and eyelash change after latanoprost was 56.5% and 46.2% at 12 months in Japanese patients

In contrast to non-pseudoexfoliative open-angle glaucoma, deep sclerectomy or viscocanaliculostomy were successful in only 12% without YAG goniopucture in pseudoexfoliative glaucoma during the 18 months follow-up

There is striking molecular evidence that high intraocular pressure induced retinal injury shares many of the gene expression changes that are characteristic of other neurodegenerative diseases in a rat model

Pretreatment and early posttreatment with EGb 761 (Ginkgo biloba) is an effective neuroprotectant in a rat model of chronic glaucoma

IOP measurements in aniridia should be performed with techniques other than applanation tonometry because of markedly thick corneas

The more important result was that the model's response became linear when the depths of perimetric defects and the losses of ganglion cells were both expressed as percentages of normal, i.e., linear units

GDX: 48% to 95% of the variation in differential light sensitivity (DLS) was not explained by RNFL retardance

The eye with the disc hemorrhage had a smaller neuroretinal rim, suggesting that the frequency of detected optic disc hemorrhages increases with advancing glaucomatous optic nerve damage

Angles were estimated to be narrower on UBM examination than on gonioscopy

MMP-9 and MMP-14 were simultaneously up-regulated, whereas TIMP-1 was slightly enhanced in mononuclear blood cells in NTG patients

Unilateral eye-drop trials may not be as adequate as supposed

Systemic treatment may be necessary to fully inhibit inflammation from the point of view of scarring

Issue 6-1

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