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Basic Science Editor's Selection
423 comments — showing 1 to 25 · all topics
Do your genes predict your visual field loss pattern?
Mahantesh Biradar & Anthony Khawaja on: Genetic Risk for Open-Angle Glaucoma Subtypes Is Associated with Specific Visual Field Defect Classes IGR 25-4 | 2026
B vitamins and choline as neuroprotective agents: the metabolic angle
Katharina Bell & Jonathan Crowston on: Dysfunctional one-carbon metabolism identifies vitamins B, B, B, and choline as neuroprotective in glaucoma IGR 25-3 | 2025
IOP is not the only culprit, genome studies say
Mahantesh Biradar & Anthony Khawaja on: GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma IGR 25-2 | 2025
Can Insulin be neuroprotective for RGCs?
James Morgan on: Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma IGR 25-1 | 2025
Glaucoma and metabolic dysfunction under pressure
Robert Casson on: Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia IGR 24-4 | 2024
Astrocytes: what turns them from friend to foe?
David Calkins on: A molecular switch for neuroprotective astrocyte reactivity IGR 24-4 | 2024
Trabecular Pigmentation is not correlated to Outflow
Rami Darwich & Arthur Sit on: Lack of Correlation Between Segmental Trabecular Meshwork Pigmentation and Angiographically Determined Outflow in Ex-Vivo Human Eyes IGR 24-3 | 2024
POAG and Plasma Metabolites
Subhabrata Chakrabarti on: Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank IGR 24-1/2 | 2024
Modelling the biomechanics of the ONH and cornea
Arthur Sit on: The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study IGR 23-4 | 2023
Histo-architectural effects of IOP
Michael Girard on: Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell IGR 23-4 | 2023
learnings from a classic rodent model
Robert Nickells on: Natural History of Glaucoma Progression in the DBA/2J Model: Early Contribution of Müller Cell Gliosis IGR 23-4 | 2023
Single-RGC detection of functional impairment
Francesca Cordeiro on: Longitudinal in vivo Ca imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level IGR 23-3 | 2023
Neuroprotection through mitochondrial transport restoration
Makoto Aihara on: Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function IGR 23-3 | 2023
Neuroprotection through mitochondrial transport restoration
Kevin Park on: Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function IGR 23-3 | 2023
Insights into the pharmacology of a selective EP2-R agonist
Makoto Aihara on: Downregulation of COL12A1 and COL13A1 by a selective EP2 receptor agonist, omidenepag, in human trabecular meshwork cells IGR 23-3 | 2023
Monitoring outflow facility in rats
Darryl Overby & Joseph van Batenburg-Sherwood on: A portable feedback-controlled pump for monitoring eye outflow facility in conscious rats IGR 23-3 | 2023
IOP and Iron Homeostasis
Shan Lin on: Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma IGR 23-2 | 2023
Are Pericytes the Missing Link Between IOP and Functional Damage?
David Calkins on: Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma IGR 22-4 | 2022
Neuroprotection in a preclinical model I
Derek Welsbie on: BCLX gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma IGR 22-3 | 2022
Neuroprotection after Optic Nerve Injury
Derek Welsbie on: Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury IGR 22-2 | 2021
Stem cell replacement of retinal ganglion cells - I
Thomas Johnson on: The role of PGS/PCL scaffolds in promoting differentiation of human embryonic stem cells into retinal ganglion cells IGR 22-1 | 2021
Endoplasmic Reticulum Protein Load and Glaucoma
Katie Bollinger & Barbara Mysona on: ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load IGR 21-4 | 2021
Energy Metabolism and Neuroprotection
Adriana DiPolo on: Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin IGR 21-4 | 2021
Protecting RGCs from Oxidative Stress
Toru Nakazawa on: Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function IGR 21-4 | 2021
Stem Cells and RGC Replacement
Keith Martin on: Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells IGR 21-4 | 2021
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